P002 Inhibition of Axl signaling by BGB324 reduces fibrogenesis in human intestinal cells and human intestinal organoids
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چکیده
منابع مشابه
Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells.
Urolithiasis remains a very common disease in Western countries. Seventy to eighty percent of kidney stones are composed of calcium oxalate, and minor changes in urinary oxalate affect stone risk. Intestinal oxalate secretion mediated by anion exchanger SLC26A6 plays a major constitutive role in limiting net absorption of ingested oxalate, thereby preventing hyperoxaluria and calcium oxalate ur...
متن کاملHuman Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.
Identification of Lgr5 as the intestinal stem cell marker as well as the growth factors necessary to replicate adult intestinal stem cell division has led to the establishment of the methods to generate "indefinite" ex vivo primary intestinal epithelial cultures, termed "mini-intestines." Primary cultures developed from isolated intestinal crypts or stem cells (termed enteroids/colonoids) and f...
متن کاملInteraction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells
The intestinal mucosa forms the first line of defense against infections mediated by enteric pathogens such as salmonellae. Here we exploited intestinal "organoids" (iHOs) generated from human induced pluripotent stem cells (hIPSCs) to explore the interaction of Salmonella enterica serovar Typhimurium with iHOs. Imaging and RNA sequencing were used to analyze these interactions, and clear chang...
متن کاملIntestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli
Infection with Shiga toxin (Stx) producing Escherichia coli O157:H7 can cause the potentially fatal complication hemolytic uremic syndrome, and currently only supportive therapy is available. Lack of suitable animal models has hindered study of this disease. Induced human intestinal organoids (iHIOs), generated by in vitro differentiation of pluripotent stem cells, represent differentiated huma...
متن کاملcase report of human intestinal myiasis caused by lucilia illustris
conclusions intestinal myiasis in humans is probably an accidental myiasis, related to the ingestion of contaminated uncooked food or water containing fly larvae, especially in individuals with poor hygienic conditions. nevertheless, this is the first reported case of intestinal myiasis due to l. illustris in iran. case presentation herein, we present a case of accidental human intestinal myias...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2017
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjx002.129